Open AccessBy Hook or by Crook: Multifaceted DNA-Binding Properties of MeCP2
Author(s) -
Jaehoon Shin,
Guoli Ming,
Hongjun Song
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.02.017
Subject(s) - mecp2 , rett syndrome , biology , dna methylation , chromatin , epigenetics , cpg site , genetics , x inactivation , gene , dna , histone , microbiology and biotechnology , gene expression , x chromosome , phenotype
Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom