The Origins and Drivers of Insulin Resistance | Zendy

Andrew M. Johnson | Zendy; Jerrold M. Olefsky | Zendy

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The Origins and Drivers of Insulin Resistance

Author(s) -

Andrew M. Johnson,

Jerrold M. Olefsky

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.01.041

Subject(s) - biology , insulin resistance , resistance (ecology) , insulin , genetics , microbiology and biotechnology , ecology

Obesity-induced insulin resistance is the major determinant of metabolic syndrome, which precedes the development of type 2 diabetes mellitus and is thus the driving force behind the emerging diabetes epidemic. The precise causes of insulin resistance are varied, and the relative importance of each is a matter of ongoing research. Here, we offer a Perspective on the heterogeneous etiology of insulin resistance, focusing in particular on the role of inflammation, lipid metabolism, and the gastrointestinal microbiota.

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