Open AccessA Mouse Following in the Footsteps of Human Prehistory
Author(s) -
Samuel H. Vohr,
Richard E. Green
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.01.039
Subject(s) - biology , phenotype , genetics , positive selection , selection (genetic algorithm) , prehistory , evolutionary biology , nail (fastener) , transgene , gene , computer science , materials science , metallurgy , paleontology , artificial intelligence
One of the strongest signals of positive selection in humans surrounds the V370A variant of Ectodysplasin A receptor (EDAR). However, its phenotypic consequences and impetus for selection are not well understood. Kamberov et al. nail down when it originated and, using transgenic mice, delineate its phenotypic impacts.
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