Open AccessConformational Ensembles in GPCR Activation
Author(s) -
Eyal Vardy,
Bryan L. Roth
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.01.025
Subject(s) - g protein coupled receptor , biology , structural biology , computational biology , drug discovery , chemical biology , receptor , small molecule , bioinformatics , biochemistry
Recent advances in G-protein-coupled receptor structural biology have provided only limited insight into the active conformations of these key signaling molecules. A paper from Nygaard et al. reveals the dynamic nature of GPCRs along the activation pathway by complementing NMR experiments with ultralong-timescale molecular dynamics simulations.
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