Open AccessThe Role of Telomeres in Stem Cells and Cancer
Author(s) -
Çagatay Güneş,
K. Lenhard Rudolph
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.01.010
Subject(s) - biology , telomere , stem cell , cancer , cancer stem cell , genetics , cancer research , microbiology and biotechnology , computational biology , dna
Telomere shortening impairs proliferation of transformed cells but also leads to cancer initiation by inducing chromosomal instability. Here, we discuss recent developments in our understanding of the role of telomeres in replication stress and how telomerase expression in somatic stem cells may affect genome integrity control and carcinogenesis.
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