Genomes on the Edge: Programmed Genome Instability in Ciliates | Zendy

John R. Bracht | Zendy; Wenwen Fang | Zendy; Aaron D. Goldman | Zendy; Egor Dolzhenko | Zendy; Elizabeth M. Stein | Zendy; Laura F. Landweber | Zendy

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Genomes on the Edge: Programmed Genome Instability in Ciliates

Author(s) -

John R. Bracht,

Wenwen Fang,

Aaron D. Goldman,

Egor Dolzhenko,

Elizabeth M. Stein,

Laura F. Landweber

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.01.005

Subject(s) - biology , genome , noncoding dna , evolutionary biology , genetics , epigenetics , rna , transposable element , tetrahymena , computational biology , gene

Ciliates are an ancient and diverse group of microbial eukaryotes that have emerged as powerful models for RNA-mediated epigenetic inheritance. They possess extensive sets of both tiny and long noncoding RNAs that, together with a suite of proteins that includes transposases, orchestrate a broad cascade of genome rearrangements during somatic nuclear development. This Review emphasizes three important themes: the remarkable role of RNA in shaping genome structure, recent discoveries that unify many deeply diverged ciliate genetic systems, and a surprising evolutionary "sign change" in the role of small RNAs between major species groups.

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