Open AccessBlending Hippo and WNT: Sharing Messengers and Regulation
Author(s) -
Becky Pinjou Tsai,
Nate P. Hoverter,
Marian L. Waterman
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.12.007
Subject(s) - biology , wnt signaling pathway , yap1 , hippo signaling pathway , transcription factor , microbiology and biotechnology , kinase , signal transduction , genetics , gene
Two new studies reveal ways in which the Wnt pathway commandeers Hippo components for signaling. Azzolin et al. show how the Hippo transcription factor TAZ mediates Wnt signals, and Rosenbluh et al. show how β-catenin and YAP1 form a kinase-regulated complex with transcription factor TBX5.
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