Open AccessLoaded Dice for Human Genome Mutation
Author(s) -
Chris P. Ponting
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.12.002
Subject(s) - biology , dice , genetics , mutation , genome , human genome , computational biology , gene , geometry , mathematics
Not all bases in the human genome are equally prone to chance mutations. Michaelson et al. show that individuals can acquire clusters of de novo DNA changes and propose that the likelihood of single base pair change differs across three orders of magnitude.
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