Open AccessSmall RNAs of Opposite Sign… but Same Absolute Value
Author(s) -
Erik J. Sontheimer
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.11.032
Subject(s) - biology , piwi interacting rna , small nucleolar rna , genome , genetics , sign (mathematics) , gene silencing , microrna , long non coding rna , rna , computational biology , gene , transposable element , mathematical analysis , mathematics
In ciliates, small RNAs have been shown to target foreign sequences for silencing via elimination from the somatic genome. Fang et al. now reveal a set of Piwi-interacting RNAs (piRNAs) in Oxytricha trifallax that likewise enable genomic self versus nonself discrimination, this time by specifying self sequences for genome retention.
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