SIRT6 Puts Cancer Metabolism in the Driver’s Seat | Zendy

Costas A. Lyssiotis | Zendy; Lewis C. Cantley | Zendy

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SIRT6 Puts Cancer Metabolism in the Driver’s Seat

Author(s) -

Costas A. Lyssiotis,

Lewis C. Cantley

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.11.020

Subject(s) - biology , carcinogenesis , cancer cell , signal transduction , cancer , hyperactivation , metabolism , cancer research , cell growth , suppressor , microbiology and biotechnology , reprogramming , sirt6 , genetics , cell , biochemistry , gene , sirtuin , acetylation

The rewiring of metabolism in cancer is thought to result from hyperactivation of signaling pathways that instruct cells to grow. Sebastian et al. show that loss of the tumor suppressor SIRT6 transforms cells by activating tumor metabolism. This occurs independently of mutations in canonical growth signaling pathways and reveals a tumorigenic role for cancer metabolism.

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