Open AccessA Mediator Lost in the War on Cancer
Author(s) -
Xing Guo,
Xiaofan Wang
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.11.003
Subject(s) - mediator , biology , protein subunit , cancer research , transforming growth factor , signal transduction , drug resistance , bioinformatics , gene , microbiology and biotechnology , genetics
An unexpected role for a Mediator subunit, MED12, in resistance to multiple anticancer agents is revealed by Huang et al. Loss of MED12 confers drug resistance by activating transforming growth factor b (TGF-b) signaling. Inhibition of the TGF-b pathway resensitizes cells to therapeutic drugs, suggesting a new combinatorial cancer treatment.
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