Comprehensive Analysis of Silencing Mutants Reveals Complex Regulation of the Arabidopsis Methylome | Zendy

Hume Stroud | Zendy; Max Greenberg | Zendy; Suhua Feng | Zendy; Yana V. Bernatavichute | Zendy; Steven E. Jacobsen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Comprehensive Analysis of Silencing Mutants Reveals Complex Regulation of the Arabidopsis Methylome

Author(s) -

Hume Stroud,

Max Greenberg,

Suhua Feng,

Yana V. Bernatavichute,

Steven E. Jacobsen

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.10.054

Subject(s) - biology , arabidopsis , mutant , dna methylation , gene silencing , genetics , methylation , computational biology , microbiology and biotechnology , gene , gene expression

Cytosine methylation is involved in various biological processes such as silencing of transposable elements (TEs) and imprinting. Multiple pathways regulate DNA methylation in different sequence contexts, but the factors that regulate DNA methylation at a given site in the genome largely remain unknown. Here we have surveyed the methylomes of a comprehensive list of 86 Arabidopsis gene silencing mutants by generating single-nucleotide resolution maps of DNA methylation. We find that DNA methylation is site specifically regulated by different factors. Furthermore, we have identified additional regulators of DNA methylation. These data and analyses will serve as a comprehensive community resource for further understanding the control of DNA methylation patterning.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research