Open AccessMacrolides: The Plug Is Out
Author(s) -
Martin Gamerdinger,
Elke Deuerling
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.10.015
Subject(s) - biology , in vivo , ribosomal protein , computational biology , ribosomal rna , antibiotics , in vitro , microbiology and biotechnology , genetics , ribosome , gene , rna
Macrolide antibiotics are thought to clog up the ribosomal tunnel and thereby block general protein synthesis. By using a combination of elegant in vivo and in vitro approaches, Kannan et al. show that the inhibitory action of these drugs on bacterial protein synthesis is selective rather than global.
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