Open AccessA Missing Link in Genotype-Directed Cancer Therapy
Author(s) -
René Bernards
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.10.014
Subject(s) - biology , genotype , crosstalk , cancer therapy , cancer drugs , computational biology , cancer , precision medicine , genetics , bioinformatics , gene , physics , optics
Genotype-directed therapy holds great promise for the treatment of cancer, but crosstalk between signaling pathways often confounds simple genotype-drug response relationships. To deliver on the promise of precision medicine, a coordinated effort is needed to make a comprehensive inventory of the many signaling feedback circuits that exist in cancer cells.
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