Open AccessA Helicase with an Extra Spring in Its Step
Author(s) -
Michael Schlierf,
Taekjip Ha
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.09.031
Subject(s) - biology , helicase , dnab helicase , replisome , dna , dna replication , nucleotide , base pair , primase , genetics , biophysics , microbiology and biotechnology , computational biology , circular bacterial chromosome , gene , rna , reverse transcriptase
DNA replication requires hexameric ring-shaped helicases that unwind double-stranded DNA. In this issue, Itsathitphaisarn et al. report a high-resolution crystal structure of DnaB in complex with single-stranded DNA and nucleotide triphosphate analogs, revealing a unique mechanism by which DnaB unwinds DNA two base pairs at a time.
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