A Circuit Mechanism for Neurodegeneration | Zendy

Francesco Roselli | Zendy; Pico Caroni | Zendy

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A Circuit Mechanism for Neurodegeneration

Author(s) -

Francesco Roselli,

Pico Caroni

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.09.030

Subject(s) - biology , smn1 , spinal muscular atrophy , neuroscience , neurodegeneration , mechanism (biology) , degeneration (medical) , cholinergic , sensory system , rna splicing , motor neuron , spinal cord , disease , rna , genetics , gene , medicine , philosophy , epistemology , pathology

How deficiency in SMN1 selectively affects motoneurons in spinal muscular atrophy is poorly understood. Here, Imlach et al. and Lotti et al. show that aberrant splicing of Stasimon in cholinergic sensory neurons and interneurons leads to motoneuron degeneration, suggesting that altered circuit function may underlie the disorder.

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