Open AccessThe Problem with Mixing Mitochondria
Author(s) -
Nick Lane
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.09.028
Subject(s) - heteroplasmy , biology , mixing (physics) , mitochondrion , genetics , mitochondrial dna , phenotype , bioenergetics , haplotype , interference (communication) , evolutionary biology , allele , gene , physics , quantum mechanics , channel (broadcasting) , electrical engineering , engineering
Mixing of mitochondrial DNAs (heteroplasmy) is unfavorable for reasons unknown. Sharpley et al. show that heteroplasmy has surprising genetic and behavioral effects in mice, even when each haplotype alone produces a normal phenotype. This interference is bioenergetic and may have contributed to the evolution of sexes.
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