Singles Engage the RNA Interference Pathway | Zendy

Beverly L. Davidson | Zendy; Alex Mas Monteys | Zendy

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Singles Engage the RNA Interference Pathway

Author(s) -

Beverly L. Davidson,

Alex Mas Monteys

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.08.008

Subject(s) - biology , trans acting sirna , small interfering rna , rna silencing , rna interference , gene silencing , rna , oligonucleotide , gene expression , rna induced silencing complex , argonaute , dna directed rna interference , small nucleolar rna , microbiology and biotechnology , gene , genetics , long non coding rna

Single-stranded RNAs interact with components of the RNA interference pathway to reduce the expression of target mRNAs. Now, Lima et al. and Yu et al. show that, with extensive chemical modifications, small single-stranded RNAs can robustly induce gene silencing with efficacy similar to their double-stranded counterparts.

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