Holding on through DNA Replication: Histone Modification or Modifier? | Zendy

Susan M. Abmayr | Zendy; Jerry L. Workman | Zendy

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Holding on through DNA Replication: Histone Modification or Modifier?

Author(s) -

Susan M. Abmayr,

Jerry L. Workman

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.08.006

Subject(s) - biology , histone , dna replication , replication (statistics) , dna , genetics , posttranslational modification , microbiology and biotechnology , computational biology , biochemistry , virology , enzyme

Histone methylation is widely believed to contribute to epigenetic inheritance by persevering through DNA replication and subsequently templating methylation of daughter chromosome regions. However, a report in this issue (Petruk et al.) suggests that chromatin association of the methytransferase complexes themselves persists through replication and re-establishes histone methylation.

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