Open AccessHippo Signaling Goes Long Range
Author(s) -
Verónica A. Codelia,
Kenneth D. Irvine
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.07.020
Subject(s) - biology , hippo signaling pathway , range (aeronautics) , microbiology and biotechnology , signal transduction , evolutionary biology , materials science , composite material
The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.
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