Open AccessExposing Secrets of Telomere-Telomerase Encounters
Author(s) -
Jean-François Noël,
Raymund J. Wellinger
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.07.015
Subject(s) - telomere , biology , telomerase , cajal body , genetics , microbiology and biotechnology , dna , gene , rna , rna splicing
In order for telomeres to remain functional and stable, they must rendezvous with the enzyme telomerase in a productive manner. In human cells, this interaction is mediated by Cajal bodies as matchmaker, and now Zhong et al. reveal molecular determinants that establish good chemistry between the two partners.
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