Transcription, Splicing, and Release: Are We There Yet? | Zendy

Ranjan Sen | Zendy; Sebastian D. Fugmann | Zendy

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Transcription, Splicing, and Release: Are We There Yet?

Author(s) -

Ranjan Sen,

Sebastian D. Fugmann

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.07.004

Subject(s) - biology , rna splicing , chromatin , intron , microbiology and biotechnology , transcription (linguistics) , proinflammatory cytokine , rna , gene expression , gene , genetics , inflammation , immunology , linguistics , philosophy

A systematic analysis of LPS-induced gene expression in macrophages by Bhatt et al. demonstrates that inflammatory responses are governed primarily at the level of transcription initiation. Unexpectedly, full-length nascent RNAs that contain introns appear to accumulate on chromatin, presumably to complete processing, prior to release of functional mRNA for export to the cytoplasm.

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