Open AccessThe Split Personality of CENP-A Nucleosomes
Author(s) -
Frederick G. Westhorpe,
Aaron F. Straight
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.07.003
Subject(s) - biology , nucleosome , histone , eukaryotic cell , histone h3 , yeast , cell cycle , genetics , microbiology and biotechnology , histone methylation , histone code , cell , dna , gene , dna methylation , gene expression
The composition and structure of centromeric nucleosomes, which contain the histone H3 variant CENP-A, is intensely debated. Two independent studies in this issue, in yeast and human cells, now suggest that CENP-A nucleosomes adopt different structures depending on the stage of the cell cycle.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom