Unfolding the Bridge between Transcription and Translation | Zendy

Vladimir Svetlov | Zendy; Evgeny Nudler | Zendy

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Unfolding the Bridge between Transcription and Translation

Author(s) -

Vladimir Svetlov,

Evgeny Nudler

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.06.025

Subject(s) - biology , transcription (linguistics) , operon , ribosome , microbiology and biotechnology , transcription factor , translation (biology) , genetics , computational biology , messenger rna , rna , gene , mutant , philosophy , linguistics

Transcription antiterminator RfaH alternates between closed (inactive) and open (activated) conformation. In this issue of Cell, Burmann et al. show that opening is accompanied by dramatic all-α to all-β refolding of its C-terminal domain. Each of the folds has a distinct function: all-α-fold acts as a specificity determinant, directing RfaH to a small subset of operons, whereas the all-β-fold recruits ribosome, thereby coupling RfaH-stimulated transcription to translation.

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