Open AccessMaternal-Fetal Immune Tolerance, Block by Block
Author(s) -
Michael Gobert,
Juan J. Lafaille
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.06.020
Subject(s) - biology , placentation , immune system , fetus , antigen , immunology , immune tolerance , embryo , pregnancy , microbiology and biotechnology , placenta , genetics
How difficult is to go from egg to implanted embryo? The evolution of placentation in eutherian mammals created enormous challenges, in particular to the maternal immune system, as the fetus expresses paternal antigens that are capable of triggering immune rejection. Samstein et al. reveal a role for inducible regulatory T cells in the enforcement of maternal-fetal immune tolerance.
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