Open AccessTiki Casts a Spell on Wnt
Author(s) -
JeanPaul Vincent,
Tony Magee
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.06.007
Subject(s) - biology , wnt signaling pathway , spell , microbiology and biotechnology , signal transduction , genetics , evolutionary biology , sociology , anthropology
Negative feedback is a widespread feature of signaling pathways. In an unexpected twist described in this issue, He and colleagues identify a membrane-tethered metalloprotease named Tiki that inhibits Wnt signaling by removing an essential eight-residue fragment from Wnt itself.
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