Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human | Zendy

Jun Wu | Zendy; Pontus Boström | Zendy; Lauren M. Sparks | Zendy; Li Ye | Zendy; Jang Hyun Choi | Zendy; An-Hoa Giang | Zendy; Melin J. Khandekar | Zendy; Kirsi A. Virtanen | Zendy; Pirjo Nuutila | Zendy; Gert Schaart | Zendy; Kexin Huang | Zendy; Hua Tu | Zendy; Wouter D. van Marken Lichtenbelt | Zendy; Joris Hoeks | Zendy; Sven Enerbäck | Zendy; Patrick Schrauwen | Zendy; Bruce M. Spiegelman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

Author(s) -

Jun Wu,

Pontus Boström,

Lauren M. Sparks,

Li Ye,

Jang Hyun Choi,

An-Hoa Giang,

Melin J. Khandekar,

Kirsi A. Virtanen,

Pirjo Nuutila,

Gert Schaart,

Kexin Huang,

Hua Tu,

Wouter D. van Marken Lichtenbelt,

Joris Hoeks,

Sven Enerbäck,

Patrick Schrauwen,

Bruce M. Spiegelman

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.05.016

Subject(s) - biology , adipose tissue , microbiology and biotechnology , thermogenesis , cell , cell type , genetics , endocrinology

Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation of "beige" cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential. PAPERCLIP:

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research