Open AccessWnt/β-Catenin Signaling and Disease
Author(s) -
Hans Clevers,
Roel Nusse
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.05.012
Subject(s) - biology , wnt signaling pathway , disease , catenin , beta catenin , signal transduction , microbiology and biotechnology , lrp6 , computational biology , genetics , cancer research , medicine
The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.
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