Open AccessIt Takes KASH to Hitch to the SUN
Author(s) -
Brian Burke
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.05.004
Subject(s) - nuclear lamina , biology , lamin , cytoskeleton , inner membrane , nuclear matrix , microbiology and biotechnology , nucleus , nuclear protein , cell , genetics , transcription factor , gene , mitochondrion , chromatin
LINC complexes are structures embedded within the nuclear envelope that mechanically couple the nucleus and cytoskeleton. They consist of SUN domain proteins of the inner nuclear membrane associated with KASH domain proteins in the outer nuclear membrane. Atomic resolution structures of SUN-KASH pairs now provide new insight in to the mechanisms of LINC complex assembly
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