Sibling Rivalry among Paralogs Promotes Evolution of the Human Brain | Zendy

Chris TylerSmith | Zendy; Yali Xue | Zendy

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Sibling Rivalry among Paralogs Promotes Evolution of the Human Brain

Author(s) -

Chris TylerSmith,

Yali Xue

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.04.020

Subject(s) - biology , gene duplication , evolutionary biology , rivalry , sibling rivalry (animals) , neuroscience , adaptive evolution , human evolution , human brain , sibling , cognitive science , genetics , gene , developmental psychology , psychology , economics , macroeconomics

Geneticists have long sought to identify the genetic changes that made us human, but pinpointing the functionally relevant changes has been challenging. Two papers in this issue suggest that partial duplication of SRGAP2, producing an incomplete protein that antagonizes the original, contributed to human brain evolution.

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