Network Medicine Strikes a Blow against Breast Cancer | Zendy

Janine T. Erler | Zendy; Rune Linding | Zendy

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Network Medicine Strikes a Blow against Breast Cancer

Author(s) -

Janine T. Erler,

Rune Linding

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.04.014

Subject(s) - biology , breast cancer , cancer , triple negative breast cancer , signal transduction , systems biology , cancer research , drug discovery , cancer cell , computational biology , microbiology and biotechnology , bioinformatics , genetics

Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.

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