Open AccessBreathe in and Straighten Your Back: Hypoxia, Notch, and Scoliosis
Author(s) -
Lola Bajard,
Andrew C. Oates
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.03.024
Subject(s) - biology , hypoxia (environmental) , scoliosis , neuroscience , anatomy , genetics , oxygen , physics , quantum mechanics
In this issue of Cell, Sparrow et al. propose a new mechanism for sporadically occurring congenital scoliosis in which Notch signaling and hypoxia converge in the embryo on somite patterning via the segmentation clock. This interaction between hypoxia and a predisposed genetic background might underlie other birth defects with incomplete penetrance.
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