Open AccessSnapShot: Lung Cancer Models
Author(s) -
Anna F. Farago,
Eric L. Snyder,
Tyler Jacks
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.03.015
Subject(s) - biology , snapshot (computer storage) , lung cancer , computational biology , medicine , computer science , operating system
from endogenous locus. Viral cre delivery via adenoviral or lentiviral inoculation (intranasal or intratracheal).Adenocarcinoma spectrum histology (i.e., in situ and invasive neoplasia) in lung; metastasis not reported.K-ras somatic mutations identified in ~20%-30% of lung adenocarcinomas. Mouse models of the oncogenic K-ras allele have been used in preclinical studies of cisplatin resistance and combination targeted therapies.K-ras
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