A Molecular Doorstop Ensures a Trickle through Translational Repression | Zendy

Matthew Brook | Zendy; Richard W. Smith | Zendy; Nicola K. Gray | Zendy

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A Molecular Doorstop Ensures a Trickle through Translational Repression

Author(s) -

Matthew Brook,

Richard W. Smith,

Nicola K. Gray

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.03.010

Subject(s) - biology , psychological repression , trickle , genetics , microbiology and biotechnology , computational biology , gene , gene expression , political science , law

Switching mRNA translation off and on is central to regulated gene expression, but what mechanisms moderate the extent of switch-off? Yao et al. describe how basal expression from interferon-gamma-induced transcripts is maintained during mRNA-specific translational repression. This antagonistic mechanism utilizes a truncated RNA-binding factor generated by a unique alternative polyadenylation event.

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