Open AccessCOPII Vesicles Get Supersized by Ubiquitin
Author(s) -
Vivek Malhotra
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.03.006
Subject(s) - copii , biology , endoplasmic reticulum , vesicle , copi , microbiology and biotechnology , vesicular transport proteins , procollagen peptidase , biochemistry , membrane , secretory pathway , golgi apparatus , cytoplasm , vacuole , vacuolar protein sorting
Some proteins are too big to fit into conventional COPII-coated vesicles, which raises the question of how large cargo, such as procollagen fibrils, are exported from the endoplasmic reticulum. Jin et al. (2012) in Nature now report that the creation of oversized vesicles is facilitated by the ubiquitination of the COPII component Sec31p.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom