Deconstructing the Complexity of a Microenvironmental Niche | Zendy

Daniela S. Krause | Zendy; David T. Scadden | Zendy

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Deconstructing the Complexity of a Microenvironmental Niche

Author(s) -

Daniela S. Krause,

David T. Scadden

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.03.005

Subject(s) - biology , niche , context (archaeology) , microbiology and biotechnology , heterologous , extracellular matrix , cell signaling , stem cell niche , signal transduction , genetics , stem cell , ecology , gene , progenitor cell , paleontology

Cells acquire their fate in vivo in the context of a complex microenvironmental "niche" comprised of heterologous cell types, signaling molecules, extracellular matrix, biophysical forces, and metabolic substrates. Now Calderón and Boehm report the "refunctionalization" of a defective thymic epithelial niche, offering insights into how signaling molecules may be hierarchically organized to direct differentiation outcomes.

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