Open AccessThe Virtues of Youth and Maturity (in Dentate Granule Cells)
Author(s) -
Colin Lever,
Neil Burgess
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.02.038
Subject(s) - biology , neurogenesis , hippocampal formation , granule (geology) , dentate gyrus , neuroscience , mutant , microbiology and biotechnology , granule cell , genetics , gene , paleontology
How does adult neurogenesis contribute to memory? Nakashiba and colleagues generated mutant mice in which synaptic output from older hippocampal granule cells was specifically blocked. Experiments with these mice reveal an unpredicted age-dependent specialization of function, demonstrating that recently born cells support pattern separation, whereas older cells support pattern completion.
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