Open AccessAntibody-Based Immunotherapy of Cancer
Author(s) -
Louis M. Weiner,
Joseph C. Murray,
Casey W. Shuptrine
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.02.034
Subject(s) - immune system , monoclonal antibody , antigen , biology , antibody , immunotherapy , cancer , immunology , cancer immunotherapy , cancer research , cancer cell , genetics
By targeting surface antigens expressed on tumor cells, monoclonal antibodies have demonstrated efficacy as cancer therapeutics. Recent successful antibody-based strategies have focused on enhancing antitumor immune responses by targeting immune cells, irrespective of tumor antigens. We discuss these innovative strategies and propose how they will impact the future of antibody-based cancer therapy.
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