Life in the Fast Lane: Mammalian Disease Models in the Genomics Era | Zendy

Lukas E. Dow | Zendy; Scott W. Lowe | Zendy

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Life in the Fast Lane: Mammalian Disease Models in the Genomics Era

Author(s) -

Lukas E. Dow,

Scott W. Lowe

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.02.023

Subject(s) - biology , computational biology , genomics , human disease , disease , systems biology , genome editing , genome , precision medicine , human genome , emerging technologies , data science , microbiology and biotechnology , genetics , computer science , gene , artificial intelligence , medicine , pathology

Analyses of the human genome have proven extremely successful in identifying changes that contribute to human disease. Genetically engineered mice provide a powerful tool to analyze these changes, although they are slow and costly and do not always recapitulate human biology. Recent advances in genomic technologies, rodent-modeling approaches, and the production of patient-derived reprogrammed cell lines now provide a plethora of complementary systems to study disease states and test new therapies. Continued evolution and integration of these model systems will be the key to realizing the benefits of the genomic revolution and refining our understanding and treatment of human diseases.

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