Open AccessDNA-Damage-Induced Differentiation in Hematopoietic Stem Cells
Author(s) -
Pankaj Kumar Mandal,
Derrick J. Rossi
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.02.011
Subject(s) - biology , haematopoiesis , stem cell , dna damage , transcription factor , microbiology and biotechnology , g2 m dna damage checkpoint , cellular differentiation , dna , genetics , cell cycle checkpoint , cell cycle , gene
Aging of hematopoietic stem cells (HSCs) is accompanied by diminished functional potential. Wang et al. now provide evidence for an HSC-specific differentiation checkpoint mediated by the transcription factor BATF, which limits self-renewal of HSCs in response to the accumulation of DNA damage.
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