Open AccessSynaptic Vesicle Distribution by Conveyor Belt
Author(s) -
Armen J. Moughamian,
Erika L.F. Holzbaur
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.02.007
Subject(s) - synaptic vesicle , axon , synaptic pharmacology , biology , synapse , neuroscience , neurotransmission , vesicle , neuron , synaptic augmentation , synaptic plasticity , microbiology and biotechnology , inhibitory postsynaptic potential , receptor , biochemistry , excitatory postsynaptic potential , membrane
The equal distribution of synaptic vesicles among synapses along the axon is critical for robust neurotransmission. Wong et al. show that the continuous circulation of synaptic vesicles throughout the axon driven by molecular motors ultimately yields this even distribution.
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