Open AccessInnate Immunity to TB: A Druggable Balancing Act
Author(s) -
Ajit Lalvani,
Marcel A. Behr,
Saranya Sridhar
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.01.026
Subject(s) - biology , druggability , innate immune system , immunity , virology , immunology , computational biology , genetics , immune system , gene
Tobin and colleagues show that both inhibition and excessive production of the inflammatory mediator TNFα impact the pathogenesis of tuberculosis (TB) and the response to therapy. Identifying a critical role for the genetically determined balance between pro- and anti-inflammatory eicosanoids in regulating TNFα levels provides a roadmap to tailored TB treatment based on host genotype.
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