Open AccessImmune Cells Exploit a Neural Circuit to Enter the CNS
Author(s) -
Kevin J. Tracey
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.01.025
Subject(s) - biology , neuroscience , spinal cord , immune system , multiple sclerosis , central nervous system , neural stem cell , microbiology and biotechnology , immunology , stem cell
Multiple sclerosis (MS) is associated with the appearance of autoreactive T cells in the central nervous system. Using a mouse model of MS, Arima et al. now show that this attack begins at a specific spinal cord location. T cell entry into the CNS is regulated by a reflex neural circuit originating from leg muscle contractions.
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