Open AccessA New Histone at the Centromere?
Author(s) -
Daniel R. Foltz,
P. Todd Stukenberg
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.01.023
Subject(s) - centromere , biology , kinetochore , chromatin , histone , genetics , histone h3 , microbiology and biotechnology , histone code , epigenetics , computational biology , nucleosome , chromosome , gene
The centromere is a classic system to study epigenetic specification, and most research has focused on a specialized histone variant, CENP-A, that is required for kinetochore assembly. Now Nishino et al. reveal a new level of complexity for centromeric chromatin, by showing that the kinetochore complex CENP-T-W-S-X shares structural and functional properties with canonical histones.
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