Hypoxia-Inducible Factors in Physiology and Medicine | Zendy

Gregg L. Semenza | Zendy

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Hypoxia-Inducible Factors in Physiology and Medicine

Author(s) -

Gregg L. Semenza

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.01.021

Subject(s) - biology , homeostasis , hypoxia inducible factors , hypoxia (environmental) , microbiology and biotechnology , transcription factor , physiology , function (biology) , bioinformatics , neuroscience , gene , oxygen , genetics , chemistry , organic chemistry

Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining pathological consequences of HIF dysregulation in chronic diseases, and investigating potential targeting of HIFs for therapeutic purposes.

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