Open AccessFGF21 and the Second Coming of PPARγ
Author(s) -
Li Qiang,
Domenico Accili
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.01.020
Subject(s) - fgf21 , biology , autocrine signalling , agonist , fibroblast growth factor , growth hormone , hormone , medicine , endocrinology , receptor , biochemistry
Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPARγ agonist class of antidiabetic drugs. Does this new property improve FGF21's fledgling clinical prospects or endorse a clinical resuscitation of PPARγ agonists?
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