The Microbial Opsin Family of Optogenetic Tools | Zendy

Feng Zhang | Zendy; Johannes Vierock | Zendy; Ofer Yizhar | Zendy; Lief E. Fenno | Zendy; Satoshi P. Tsunoda | Zendy; Arash Kianianmomeni | Zendy; Matthias Prigge | Zendy; A. Berndt | Zendy; John C. Cushman | Zendy; Jürgen E.W. Polle | Zendy; Jon Magnuson | Zendy; Peter Hegemann | Zendy; Karl Deisseroth | Zendy

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The Microbial Opsin Family of Optogenetic Tools

Author(s) -

Feng Zhang,

Johannes Vierock,

Ofer Yizhar,

Lief E. Fenno,

Satoshi P. Tsunoda,

Arash Kianianmomeni,

Matthias Prigge,

A. Berndt,

John C. Cushman,

Jürgen E.W. Polle,

Jon Magnuson,

Peter Hegemann,

Karl Deisseroth

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2011.12.004

Subject(s) - opsin , biology , optogenetics , bridging (networking) , genomics , computational biology , evolutionary biology , genetics , rhodopsin , genome , neuroscience , gene , computer science , botany , retinal , computer network

The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed. Recent advances in understanding microbial opsins have been driven by molecular engineering for optogenetics and by comparative genomics. Here we provide a Primer on these light-activated ion channels and pumps, describe a group of opsins bridging prior categories, and explore the convergence of molecular engineering and genomic discovery for the utilization and understanding of these remarkable molecular machines.

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