Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer | Zendy

Elizabeth P. Murchison | Zendy; Ole Schulz-Trieglaff | Zendy; Zemin Ning | Zendy; Ludmil B. Alexandrov | Zendy; Markus Bauer | Zendy; Beiyuan Fu | Zendy; Matthew M. Hims | Zendy; Zhihao Ding | Zendy; Sergii Ivakhno | Zendy; Caitlin M. Stewart | Zendy; Bee Ling Ng | Zendy; Wendy S.W. Wong | Zendy; Bronwen Aken | Zendy; Simon White | Zendy; Amber E. Alsop | Zendy; Jennifer Becq | Zendy; Graham R. Bignell | Zendy; R. Keira Cheetham | Zendy; William Cheng | Zendy; Thomas R. Connor | Zendy; Anthony J. Cox | Zendy; Zhiping Feng | Zendy; Yong Q. Gu | Zendy; Russell Grocock | Zendy; Simon R. Harris | Zendy; Irina Khrebtukova | Zendy; Zoya Kingsbury | Zendy; Mark Kowarsky | Zendy; Alexandre Kreiss | Zendy; Shujun Luo | Zendy; John Marshall | Zendy; David J. McBride | Zendy; Lisa Murray | Zendy; AnneMaree Pearse | Zendy; Keiran Raine | Zendy; Isabelle Rasolonjatovo | Zendy; Richard J. Shaw | Zendy; Philip Tedder | Zendy; Carolyn Tregidgo | Zendy; Albert J. Vilella | Zendy; David C. Wedge | Zendy; GM Woods | Zendy; Niall Gormley | Zendy; Sean Humphray | Zendy; Gary P. Schroth | Zendy; Geoffrey Smith | Zendy; Kevin P. Hall | Zendy; Stephen M. J. Searle | Zendy; Nigel P. Carter | Zendy; Anthony T. Papenfuss | Zendy; P. Andrew Futreal | Zendy; Peter J. Campbell | Zendy; Fengtang Yang | Zendy; David Bentley | Zendy; Dirk J. Evers | Zendy; Michael R. Stratton | Zendy

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Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer

Author(s) -

Elizabeth P. Murchison,

Ole Schulz-Trieglaff,

Zemin Ning,

Ludmil B. Alexandrov,

Markus Bauer,

Beiyuan Fu,

Matthew M. Hims,

Zhihao Ding,

Sergii Ivakhno,

Caitlin M. Stewart,

Bee Ling Ng,

Wendy S.W. Wong,

Bronwen Aken,

Simon White,

Amber E. Alsop,

Jennifer Becq,

Graham R. Bignell,

R. Keira Cheetham,

William Cheng,

Thomas R. Connor,

Anthony J. Cox,

Zhiping Feng,

Yong Q. Gu,

Russell Grocock,

Simon R. Harris,

Irina Khrebtukova,

Zoya Kingsbury,

Mark Kowarsky,

Alexandre Kreiss,

Shujun Luo,

John Marshall,

David J. McBride,

Lisa Murray,

AnneMaree Pearse,

Keiran Raine,

Isabelle Rasolonjatovo,

Richard J. Shaw,

Philip Tedder,

Carolyn Tregidgo,

Albert J. Vilella,

David C. Wedge,

GM Woods,

Niall Gormley,

Sean Humphray,

Gary P. Schroth,

Geoffrey Smith,

Kevin P. Hall,

Stephen M. J. Searle,

Nigel P. Carter,

Anthony T. Papenfuss,

P. Andrew Futreal,

Peter J. Campbell,

Fengtang Yang,

David Bentley,

Dirk J. Evers,

Michael R. Stratton

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2011.11.065

Subject(s) - biology , genetics , genome , evolutionary biology , lineage (genetic) , gene

The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is endangered due to a transmissible facial cancer spread by direct transfer of living cancer cells through biting. Here we describe the sequencing, assembly, and annotation of the Tasmanian devil genome and whole-genome sequences for two geographically distant subclones of the cancer. Genomic analysis suggests that the cancer first arose from a female Tasmanian devil and that the clone has subsequently genetically diverged during its spread across Tasmania. The devil cancer genome contains more than 17,000 somatic base substitution mutations and bears the imprint of a distinct mutational process. Genotyping of somatic mutations in 104 geographically and temporally distributed Tasmanian devil tumors reveals the pattern of evolution and spread of this parasitic clonal lineage, with evidence of a selective sweep in one geographical area and persistence of parallel lineages in other populations.

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