Open AccessFood for Thought: Linking Caloric Intake to Behavior via Sirtuin Activity
Author(s) -
Liam Drew,
René Hen
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.11.052
Subject(s) - biology , caloric theory , food intake , sirtuin , caloric intake , feeding behavior , sirtuin 1 , food science , endocrinology , body weight , genetics , gene , downregulation and upregulation , acetylation
Sirtuins are thought to form crucial links between energy levels and cellular metabolism. Libert et al. now provide evidence that SIRT1 activity in the brain modifies mammalian emotional behavior via monoamine signaling and that changes in this pathway might contribute to human affective disorders.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom