Open AccessLock and Key to Transcription: σ-DNA Interaction
Author(s) -
Xin Liu,
David Bushnell,
Roger D. Kornberg
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.11.033
Subject(s) - biology , transcription bubble , transcription (linguistics) , dna , duplex (building) , genetics , rna polymerase , rna , polymerase , computational biology , microbiology and biotechnology , rna dependent rna polymerase , gene , linguistics , philosophy
How does RNA polymerase recognize a promoter in duplex DNA? How are the DNA strands pried apart to enable RNA synthesis? A crystal structure by Feklistov and Darst unexpectedly reveals that these two processes are interconnected.
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